Avoiding a Return to the Pre-antibiotics Era
Prior to the discovery of antibiotics, infected minor cuts and scrapes could result in amputation or even death. With the overuse of these wonder drugs, particularly in the meat and poultry industries, bacteria are becoming resistant to all classes of antibiotics. When a new antibiotic is developed, the bacteria -- often referred to as superbugs -- mutate so quickly they are resistant to the drug before very costly clinical trials are complete. Bacteria that were historically benign are now evolving into pathogens. Because of the prohibitive regulatory process, pharmaceutical companies have abandoned development of new classes of antibiotics.
Theralytix is developing solutions for drug resistant and chronic bacterial infections.
The Bacterial Pathogens that We Are Targeting
cause a variety of infections, including endocarditis, urinary tract infections, prostatitis, intra-abdominal infection, cellulitis, and wound infection.
E. coli can cause diarrhea, while others cause urinary tract infections, respiratory illness and pneumonia, and other illnesses.
Proteus spp. A common bacterium that can cause complicated UTI, especially in catherized patients.
Designated by WHO as a critical priority, can cause infections in the blood, lungs (pneumonia), or other parts of the body after surgery.?
Most people who get ill from Salmonella have diarrhea, fever, and stomach cramps; some illness may require hospitalization.
Shigella infection cause diarrhea, fever, and stomach cramps. A major cause of death due to dehydration caused by diarrhea in third world countries.
Staphylococcus spp. Boils, impetigo, food poisoning, cellulitis and toxic shock syndrome are all examples of diseases that can be caused by Staphylococcus.
cause many disorders, including strep throat, pneumonia, and wound, skin, heart valve, and bloodstream infections.?
Some Infectious Disease Statistics
Per the peer-reviewed journal BMC viral respiratory infections in COVID-19 patients predispose them to bacterial infections, and these co-infections have a worse outcome than either infection on its own.
According to CDC’s “Biggest Threats and Data” 2019 Antibiotic Resistance Threats Report, more than 2.8 million antibiotic-resistant infections occur in the U.S. each year, and more than 35,000 people die as a result. In addition, 223,900 cases of Clostridium difficile occurred in 2017 and at least 12,800 people died.
10% of the global population suffer with chronic, biofilm-based infections that do not respond to antibiotics. Among these are urinary tract infections, sinusitis, non-healing wounds and many similar bacteria-caused medical conditions.
In 2017 almost 1.6 million people died from diarrheal diseases globally. This is more than all deaths from all ‘intentional injuries’ combined in the same year. Diarrheal disease was the cause of every tenth child?s death in 2017 -- more than half a million of the 5.4 million children that died in 2017 died from diarrheal disease.
Our Solution: Broad Spectrum Phage Cocktails
Nearly unknown in most countries, phage therapy – the use of lytic bacteriophages to biocontrol pathogenic bacteria in a targeted microbiome – is on the verge of a renaissance. First discovered by an understudy of Louis Pasteur in the 1920’s, its use was obscured by the Soviet Union’s iron curtain. Because antibiotics are failing to resolve may types of bacterial infections, science is now turning to bacteriophages.